7/29/2023 0 Comments Celiac endoscopy findings![]() Genetic testing of HLA-DQ2 and HLA-DQ8 may facilitate the diagnosis. Although the sensitivity and specificity of these tests are high, false negative results can occur in mild enteropathy and in patients with IgA deficiency. These include IgA anti-endomysial antibodies (AEA), IgA tissue-transglutaminase (tTG), IgA anti-gliadin antibodies (AGA), and IgA AGA antibodies. Recently, serologic tests have been introduced as a screening tool. More than 50% of CD patients have no GI symptoms or only non specific complaints such as dyspepsia or anorexia.1 On the other hand, growing body of evidence shows that early diagnosis and treatment can reduce the risk of malignant complication such as lymphoma.2 The gold standard for the diagnosis of CD is histopathology of the small bowel3. The diagnosis of CD may be difficult because only a proportion of these with histological abnormalities exhibit classical symptoms of CD. The prevalence of Celiac Sprue in India is not documented, but is quiet prevalent in North West India. This change in prevalence may be related to increasing physician awareness as well as improved diagnostic methods. More recent studies showed that Celiac Sprue is a common disease affecting an average one in 200 white individuals. Until fairly recently, CD was thought to be relatively rare disorder with prevalence rates 0.1%. In the majority of cases, the disease enters complete clinical and histologic remission when gluten is eliminated from the diet. ![]() Dietary gluten provokes inflammation in the small intestine, characterized by accumulation of the intra-epithelial lymphocytes, development of crypt hyperplasia, and ultimately, villous atrophy. Celiac Sprue or Celiac Disease (CD) also known as gluten sensitive enteropathy is an inflammatory disorder of the small intestine, caused by the exposure to dietary gluten in genetically susceptible individuals.
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